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While low concentrations of ROS have positive effects on cell signaling, proliferation, differentiation, and apoptosis, higher concentrations of ROS contribute to the pathophysiology of a number of chronic and degenerative diseases [40]
PMID: 36684090 Mar Drugs Xanthocillin X Dimethyl Ether Exhibits Anti-Proliferative Effect on Triple-Negative Breast Cancer by Depletion of Mitochondrial Heme
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As a consequence of AKI, a significant number of oxygen free radicals are produced, endogenous antioxidants are continually depleted, and high levels of inflammatory substances are secreted, all of which contribute to kidney damage progression ( According to our published papers (Zhou et al., 2021)
